Structure-Guided Design of a High-Affinity Platelet Integrin α(IIb)β(3) Receptor Antagonist That Disrupts Mg(2+) Binding to the MIDAS

An integrin found on platelets, α(IIb)β(3) mediates platelet aggregation, and α(IIb)β(3) antagonists are effective antithrombotic agents in the clinic. Ligands bind to integrins in part by coordinating a magnesium ion (Mg(2+)) located in the β subunit metal ion–dependent adhesion site (MIDAS). Drugs...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhu, Jieqing, Choi, Won-Seok, McCoy, Joshua G., Negri, Ana, Zhu, Jianghai, Naini, Sarasija, Li, Jihong, Shen, Min, Huang, Wenwei, Bougie, Daniel, Rasmussen, Mark, Aster, Richard, Thomas, Craig J., Filizola, Marta, Springer, Timothy A., Coller, Barry S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390238/
https://ncbi.nlm.nih.gov/pubmed/22422993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003576
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