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Transformation of Pro-Leu-Gly-NH(2) Peptidomimetic Positive Allosteric Modulators of the Dopamine D(2) Receptor into Negative Modulators

[Image: see text] The synthesis of dimethyl derivatives of 5.6.5 spiro bicyclic lactam Pro-Leu-Gly-NH(2) peptidomimetics was carried out to test the hypothesis that by placing methyl groups on the β-methylene carbon of the thiazolidine ring steric bulk would be introduced into the topological space...

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Autors principals: Bhagwanth, Swapna, Mishra, Satyendra, Daya, Ritesh, Mah, Jordan, Mishra, Ram K., Johnson, Rodney L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389495/
https://ncbi.nlm.nih.gov/pubmed/22860194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200096u
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