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Allosteric Modulation of the Dopamine D(2) Receptor by Pro-Leu-Gly-NH(2) Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation

Type II β-turn mimics and polyproline II helix mimics based upon diastereoisomeric 5.6.5 spiro bicyclic scaffolds have provided two pairs of Pro-Leu-Gly-NH(2) (PLG) peptidomimetics with contrasting dopamine receptor modulating activities. Compounds 1a and 3a were found to be positive allosteric modu...

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Detalhes bibliográficos
Main Authors: Raghavan, Bhooma, Skoblenick, Kevin J., Bhagwanth, Swapna, Argintaru, Niran, Mishra, Ram K., Johnson, Rodney L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712934/
https://ncbi.nlm.nih.gov/pubmed/19271750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801575w
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