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Transformation of Pro-Leu-Gly-NH(2) Peptidomimetic Positive Allosteric Modulators of the Dopamine D(2) Receptor into Negative Modulators
[Image: see text] The synthesis of dimethyl derivatives of 5.6.5 spiro bicyclic lactam Pro-Leu-Gly-NH(2) peptidomimetics was carried out to test the hypothesis that by placing methyl groups on the β-methylene carbon of the thiazolidine ring steric bulk would be introduced into the topological space...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389495/ https://ncbi.nlm.nih.gov/pubmed/22860194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200096u |
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