Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH(2) to the dopamine D(2L) receptor: Evidence for the allosteric modulation of the dopamine receptor

The present study was undertaken to investigate the mechanistic role of L-prolyl-L-leucyl-glycinamide (PLG) in modulating agonist binding to the dopamine D(2L) receptor. Competition and displacement assays indicate that the photoaffinity-labeling peptidomimetics of PLG, 3(R)-[(4(S)-(4-azido-2-hydrox...

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Detalhes bibliográficos
Main Authors: Mann, Amandeep, Verma, Vaneeta, Basu, Dipannita, Skoblenick, Kevin J., Beyaert, Michael G. R., Fisher, Abigail, Thomas, Nancy, Johnson, Rodney L., Mishra, Ram K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907365/
https://ncbi.nlm.nih.gov/pubmed/20639138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.05.018
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