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Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors
In the mouse model of pancreas endocrine tumor, loss of Vegf (VKO) results in dramatically decreased tumor progression; however, the residual microscopic lesions show increased invasion into surrounding exocrine tissue. Double KO mice of Vegf and hypoxia inducible factor-1α (Hif-1α) showed increased...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389366/ https://ncbi.nlm.nih.gov/pubmed/22768384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00494 |
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