Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer

Individual and small clusters of cancer cells may detach from the edges of a main tumor and invade vessels, which can act as the origin of metastasis; however, the mechanism for this phenomenon is not well understood. Using cancer tissue-originated spheroids, we studied whether disturbing the 3D arc...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Piulats, Jose M., Kondo, Jumpei, Endo, Hiroko, Ono, Hiromasa, Hagihara, Takeshi, Okuyama, Hiroaki, Nishizawa, Yasuko, Tomita, Yasuhiko, Ohue, Masayuki, Okita, Kouki, Oyama, Hidejiro, Bono, Hidemasa, Masuko, Takashi, Inoue, Masahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882311/
https://ncbi.nlm.nih.gov/pubmed/29662620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24641
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