Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblast...

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Detalhes bibliográficos
Main Authors: Pàez-Ribes, Marta, Allen, Elizabeth, Hudock, James, Takeda, Takaaki, Okuyama, Hiroaki, Viñals, Francesc, Inoue, Masahiro, Bergers, Gabriele, Hanahan, Douglas, Casanovas, Oriol
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874829/
https://ncbi.nlm.nih.gov/pubmed/19249680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.01.027
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