Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblast...

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Autori principali: Pàez-Ribes, Marta, Allen, Elizabeth, Hudock, James, Takeda, Takaaki, Okuyama, Hiroaki, Viñals, Francesc, Inoue, Masahiro, Bergers, Gabriele, Hanahan, Douglas, Casanovas, Oriol
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874829/
https://ncbi.nlm.nih.gov/pubmed/19249680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.01.027
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