Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma

The poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence, GSCs with highly invasive and highly migratory activities must assume a less-motile state and proliferate to regenerate tumor mass. Elucidating the mo...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Nishikawa, Masahiro, Inoue, Akihiro, Ohnishi, Takanori, Yano, Hajime, Ozaki, Saya, Kanemura, Yonehiro, Suehiro, Satoshi, Ohtsuka, Yoshihiro, Kohno, Shohei, Ohue, Shiro, Shigekawa, Seiji, Watanabe, Hideaki, Kitazawa, Riko, Tanaka, Junya, Kunieda, Takeharu
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175402/
https://ncbi.nlm.nih.gov/pubmed/34052625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101137
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