CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma

Antiangiogenic therapy with bevacizumab (Bev), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is a common treatment for recurrent glioblastoma (GBM), but its survival benefit is limited. Resistance to Bev is thought to be a major cause of ineffectiveness on Bev therapy. T...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Med
Hauptverfasser: Nishikawa, Masahiro, Inoue, Akihiro, Ohnishi, Takanori, Yano, Hajime, Kanemura, Yonehiro, Kohno, Shohei, Ohue, Shiro, Ozaki, Saya, Matsumoto, Shirabe, Suehiro, Satoshi, Nakamura, Yawara, Shigekawa, Seiji, Watanabe, Hideaki, Kitazawa, Riko, Tanaka, Junya, Kunieda, Takeharu
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Clinical Cancer Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957167/
https://ncbi.nlm.nih.gov/pubmed/33543833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3767
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