Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors

In the mouse model of pancreas endocrine tumor, loss of Vegf (VKO) results in dramatically decreased tumor progression; however, the residual microscopic lesions show increased invasion into surrounding exocrine tissue. Double KO mice of Vegf and hypoxia inducible factor-1α (Hif-1α) showed increased...

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Hlavní autoři: Takeda, Takaaki, Okuyama, Hiroaki, Nishizawa, Yasuko, Tomita, Shuhei, Inoue, Masahiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389366/
https://ncbi.nlm.nih.gov/pubmed/22768384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00494
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