Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but is largely dispensable for normal tissue growth, suggesting that its mammalian counterpart may be exploited for selective inhibition of oncogenic growth driven by YAP hyperactivation. Here we test this hypothesis gene...

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Dettagli Bibliografici
Autori principali: Liu-Chittenden, Yi, Huang, Bo, Shim, Joong Sup, Chen, Qian, Lee, Se-Jin, Anders, Robert A., Liu, Jun O., Pan, Duojia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387657/
https://ncbi.nlm.nih.gov/pubmed/22677547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.192856.112
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