Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but is largely dispensable for normal tissue growth, suggesting that its mammalian counterpart may be exploited for selective inhibition of oncogenic growth driven by YAP hyperactivation. Here we test this hypothesis gene...

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Detalhes bibliográficos
Main Authors: Liu-Chittenden, Yi, Huang, Bo, Shim, Joong Sup, Chen, Qian, Lee, Se-Jin, Anders, Robert A., Liu, Jun O., Pan, Duojia
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387657/
https://ncbi.nlm.nih.gov/pubmed/22677547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.192856.112
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