GENE-04. THE ONCOGENIC FUNCTIONS OF YAP1-GENE FUSIONS CAN BE INHIBITED BY DISRUPTION OF YAP1-TEAD INTERACTION

Supratentorial ependymoma can be sub-stratified into clinically relevant subtypes characterized by distinct molecular features. The subtype defined by high YAP1 activity harbored two distinct YAP1 gene fusions, YAP1-MAMLD1 and YAP1-FAM118B. In addition, YAP1 gene fusions have been detected in severa...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Szulzewsky, Frank, Hoellerbauer, Pia, Wu, Hua-Jun, Cimino, P J, Michor, Franziska, Paddison, Patrick, Vasioukhin, Valeri, Holland, Eric
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Genetics and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847854/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.406
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