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Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP
The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but is largely dispensable for normal tissue growth, suggesting that its mammalian counterpart may be exploited for selective inhibition of oncogenic growth driven by YAP hyperactivation. Here we test this hypothesis gene...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Cold Spring Harbor Laboratory Press
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3387657/ https://ncbi.nlm.nih.gov/pubmed/22677547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.192856.112 |
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