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Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex

The Hippo pathway is a tumor suppressor pathway that is implicated in the regulation of organ size. The pathway has three components: the upstream regulatory factors, the kinase core, and the downstream transcriptional machinery, which consists of YAP, TAZ (transcription co-activators) and TEAD (tra...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Kaan, Hung Yi Kristal, Chan, Siew Wee, Tan, Siew Kim Joyce, Guo, Fusheng, Lim, Chun Jye, Hong, Wanjin, Song, Haiwei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435683/
https://ncbi.nlm.nih.gov/pubmed/28515457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02219-9
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