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The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

GW182 family proteins are essential for miRNA-mediated gene silencing in animal cells. They are recruited to miRNA targets via interactions with Argonaute proteins and then promote translational repression and degradation of the miRNA targets. The human and Drosophila melanogaster GW182 proteins sha...

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Bibliografiske detaljer
Main Authors: Kuzuoğlu-Öztürk, Duygu, Huntzinger, Eric, Schmidt, Steffen, Izaurralde, Elisa
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384334/
https://ncbi.nlm.nih.gov/pubmed/22402495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks218
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