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miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

miRNAs associate with Argonaute (AGO) proteins to silence the expression of mRNA targets by inhibiting translation and promoting deadenylation, decapping, and mRNA degradation. A current model for silencing suggests that AGOs mediate these effects through the sequential recruitment of GW182 proteins...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Kuzuoğlu‐Öztürk, Duygu, Bhandari, Dipankar, Huntzinger, Eric, Fauser, Maria, Helms, Sigrun, Izaurralde, Elisa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888236/
https://ncbi.nlm.nih.gov/pubmed/27009120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592901
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