Multiple Phenotypes in Huntington Disease Mouse Neural Stem Cells

Neural stem (NS) cells are a limitless resource, and thus superior to primary neurons for drug discovery provided they exhibit appropriate disease phenotypes. Here we established NS cells for cellular studies of Huntington’s disease (HD). HD is a heritable neurodegenerative disease caused by a mutat...

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Bibliographic Details
Main Authors: Ritch, James J., Valencia, Antonio, Alexander, Jonathan, Sapp, Ellen, Gatune, Leah, Sangrey, Gavin R., Sinha, Saurabh, Scherber, Cally M., Zeitlin, Scott, Sadri-Vakili, Ghazaleh, Irimia, Daniel, DiFiglia, Marian, Kegel, Kimberly B.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383872/
https://ncbi.nlm.nih.gov/pubmed/22508027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2012.03.011
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