Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

Numerous stimuli, including oncogenic signaling, DNA damage or eroded telomeres trigger proliferative arrest, termed cellular senescence. Accumulating evidence suggests that cellular senescence is a potent barrier to tumorigenesis in vivo, however oncogene induced senescence can also promote cellula...

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Main Authors: Kolesnichenko, Marina, Hong, Lixin, Liao, Rong, Vogt, Peter K., Sun, Peiqing
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383597/
https://ncbi.nlm.nih.gov/pubmed/22627671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20683
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