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Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
Numerous stimuli, including oncogenic signaling, DNA damage or eroded telomeres trigger proliferative arrest, termed cellular senescence. Accumulating evidence suggests that cellular senescence is a potent barrier to tumorigenesis in vivo, however oncogene induced senescence can also promote cellula...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383597/ https://ncbi.nlm.nih.gov/pubmed/22627671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20683 |
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