Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence

In primary mammalian cells, oncogenic ras induces premature senescence, depending on an active MEK-extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. It has been unclear how activation of the mitogenic MEK-ERK pathway by ras can confer growth inhibition. In...

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Detalhes bibliográficos
Main Authors: Wang, Weiping, Chen, Joan X., Liao, Rong, Deng, Qingdong, Zhou, Jennifer J., Huang, Shuang, Sun, Peiqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133789/
https://ncbi.nlm.nih.gov/pubmed/11971971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3389-3403.2002
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