The miR-17-92 Cluster of microRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence

In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms including apoptosis and senescence, which are compromised by additional mutations before cancers are developed. The miR-17-92 gene cluster, a polycistron encoding 6 microRNAs (miRNAs), is frequen...

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Bibliographic Details
Main Authors: Hong, Lixin, Lai, Maoyi, Chen, Michelle, Xie, Changchuan, Liao, Rong, Kang, Young Jun, Xiao, Changchun, Hu, Wen-Yuan, Han, Jiahuai, Sun, Peiqing
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970743/
https://ncbi.nlm.nih.gov/pubmed/20851997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1938
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