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A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that Notch renders progenitors competent to differentiate into ductal and endocrine cells by inducing activators of cell differentiation. Notch sig...

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Bibliografski detalji
Glavni autori: Shih, Hung Ping, Kopp, Janel L., Sandhu, Manbir, Dubois, Claire L., Seymour, Philip A., Grapin-Botton, Anne, Sander, Maike
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383226/
https://ncbi.nlm.nih.gov/pubmed/22675211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.078634
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