A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that Notch renders progenitors competent to differentiate into ductal and endocrine cells by inducing activators of cell differentiation. Notch sig...

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Détails bibliographiques
Auteurs principaux: Shih, Hung Ping, Kopp, Janel L., Sandhu, Manbir, Dubois, Claire L., Seymour, Philip A., Grapin-Botton, Anne, Sander, Maike
Format: Artigo
Langue:Inglês
Publié: Company of Biologists 2012
Sujets:
Development and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383226/
https://ncbi.nlm.nih.gov/pubmed/22675211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.078634
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