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A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that Notch renders progenitors competent to differentiate into ductal and endocrine cells by inducing activators of cell differentiation. Notch sig...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383226/ https://ncbi.nlm.nih.gov/pubmed/22675211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.078634 |
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