A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that Notch renders progenitors competent to differentiate into ductal and endocrine cells by inducing activators of cell differentiation. Notch sig...

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Bibliographische Detailangaben
Hauptverfasser: Shih, Hung Ping, Kopp, Janel L., Sandhu, Manbir, Dubois, Claire L., Seymour, Philip A., Grapin-Botton, Anne, Sander, Maike
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2012
Schlagworte:
Development and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383226/
https://ncbi.nlm.nih.gov/pubmed/22675211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.078634
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