Loss of PTEN and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice

BACKGROUND & AIMS: Intraductal papillary mucinous neoplasias (IPMN) are precancerous cystic lesions that can develop into pancreatic ductal adenocarcinomas (PDACs). These large macroscopic lesions are frequently detected during medical imaging, but it is unclear how they form or progress to PDAC...

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Publié dans:Gastroenterology
Auteurs principaux: Kopp, Janel L., Dubois, Claire L., Schaeffer, David F., Samani, Atefeh, Taghizadeh, Farnaz, Cowan, Robert W., Rhim, Andrew D., Stiles, Bangyan L., Valasek, Mark, Sander, Maike
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880733/
https://ncbi.nlm.nih.gov/pubmed/29273451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.12.007
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