Loss of PTEN and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice

BACKGROUND & AIMS: Intraductal papillary mucinous neoplasias (IPMN) are precancerous cystic lesions that can develop into pancreatic ductal adenocarcinomas (PDACs). These large macroscopic lesions are frequently detected during medical imaging, but it is unclear how they form or progress to PDAC...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Kopp, Janel L., Dubois, Claire L., Schaeffer, David F., Samani, Atefeh, Taghizadeh, Farnaz, Cowan, Robert W., Rhim, Andrew D., Stiles, Bangyan L., Valasek, Mark, Sander, Maike
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880733/
https://ncbi.nlm.nih.gov/pubmed/29273451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.12.007
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