Hnf1b controls pancreas morphogenesis and the generation of Ngn3(+) endocrine progenitors

Heterozygous mutations in the human HNF1B gene are associated with maturity-onset diabetes of the young type 5 (MODY5) and pancreas hypoplasia. In mouse, Hnf1b heterozygous mutants do not exhibit any phenotype, whereas the homozygous deletion in the entire epiblast leads to pancreas agenesis associa...

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Vydáno v:Development
Hlavní autoři: De Vas, Matias G., Kopp, Janel L., Heliot, Claire, Sander, Maike, Cereghini, Silvia, Haumaitre, Cécile
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2015
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352981/
https://ncbi.nlm.nih.gov/pubmed/25715395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.110759
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