Podocyte-Specific Loss of Cdc42 Leads to Congenital Nephropathy

Rho family GTPases are molecular switches best known for their pivotal role in dynamic regulation of the actin cytoskeleton. The prototypic members of this family are Cdc42, Rac1, and RhoA; these GTPases contribute to the breakdown of glomerular filtration and the resultant proteinuria, but their fu...

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Bibliographic Details
Main Authors: Scott, Rizaldy P., Hawley, Steve P., Ruston, Julie, Du, Jianmei, Brakebusch, Cord, Jones, Nina, Pawson, Tony
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2012
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380653/
https://ncbi.nlm.nih.gov/pubmed/22518006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011121206
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