p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

Deregulation of the p16(INK4a)-Cdk4/6-Rb pathway is commonly detected in patients with glioblastoma multiforme (GBM) and is a rational therapeutic target. Here, we characterized the p16(INK4a)-Cdk4/6-Rb pathway in the Mayo panel of GBM xenografts, established from primary tissue samples from patient...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Cen, Ling, Carlson, Brett L., Schroeder, Mark A., Ostrem, Jamie L., Kitange, Gaspar J., Mladek, Ann C., Fink, Stephanie R., Decker, Paul A., Wu, Wenting, Kim, Jung-Sik, Waldman, Todd, Jenkins, Robert B., Sarkaria, Jann N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379801/
https://ncbi.nlm.nih.gov/pubmed/22711607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados