p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

Deregulation of the p16(INK4a)-Cdk4/6-Rb pathway is commonly detected in patients with glioblastoma multiforme (GBM) and is a rational therapeutic target. Here, we characterized the p16(INK4a)-Cdk4/6-Rb pathway in the Mayo panel of GBM xenografts, established from primary tissue samples from patient...

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Détails bibliographiques
Auteurs principaux: Cen, Ling, Carlson, Brett L., Schroeder, Mark A., Ostrem, Jamie L., Kitange, Gaspar J., Mladek, Ann C., Fink, Stephanie R., Decker, Paul A., Wu, Wenting, Kim, Jung-Sik, Waldman, Todd, Jenkins, Robert B., Sarkaria, Jann N.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379801/
https://ncbi.nlm.nih.gov/pubmed/22711607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos114
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