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Bromopyridazinedione-mediated protein and peptide bioconjugation

Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The cons...

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Bibliografiske detaljer
Main Authors: Chudasama, Vijay, Smith, Mark E. B., Schumacher, Felix F., Papaioannou, Danai, Waksman, Gabriel, Baker, James R., Caddick, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379626/
https://ncbi.nlm.nih.gov/pubmed/21738916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1cc12807h
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