Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca(2+)-activated K(+) channels

Overactive bladder syndrome is frequently associated with increased detrusor smooth muscle (DSM) contractility. We tested the hypothesis that pharmacological activation of the large-conductance voltage- and Ca(2+)-activated K(+) (BK) channel with NS-1619, a selective BK channel opener, reduces the e...

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Bibliographic Details
Main Authors: Hristov, Kiril L., Parajuli, Shankar P., Soder, Rupal P., Cheng, Qiuping, Rovner, Eric S., Petkov, Georgi V.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378020/
https://ncbi.nlm.nih.gov/pubmed/22422396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00417.2011
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