Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

We investigated why the cerebrospinal fluid (CSF) concentrations of Aβ42 are lower in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Because Aβ38/42 and Aβ40/43 are distinct product/precursor pairs, these four species in the CSF together should faithfully reflect the sta...

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Main Authors: Kakuda, Nobuto, Shoji, Mikio, Arai, Hiroyuki, Furukawa, Katsutoshi, Ikeuchi, Takeshi, Akazawa, Kohei, Takami, Mako, Hatsuta, Hiroyuki, Murayama, Shigeo, Hashimoto, Yasuhiro, Miyajima, Masakazu, Arai, Hajime, Nagashima, Yu, Yamaguchi, Haruyasu, Kuwano, Ryozo, Nagaike, Kazuhiro, Ihara, Yasuo
格式: Artigo
語言:Inglês
出版: WILEY-VCH Verlag 2012
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376855/
https://ncbi.nlm.nih.gov/pubmed/22354516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200214
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