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Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells
Histone deacetylases (HDACs) and microRNAs (miRs) have pro-survival roles, but the mechanism behind this is unclear. Repression of ceramide synthase 1 (CerS1), altering C(18)-ceramide generation, was linked to drug resistance and metastasis. Here we report that the CerS1 promoter was repressed by HD...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
WILEY-VCH Verlag
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376837/ https://ncbi.nlm.nih.gov/pubmed/22180294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100189 |
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