Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

G protein-coupled receptors (GPCRs), the largest human gene family, are important regulators of signaling pathways. However, knowledge of their genetic alterations is limited. In this study, we used exon capture and massively parallel sequencing methods to analyze the mutational status of 734 GPCRs...

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Autors principals: Prickett, Todd D, Wei, Xiaomu, Cardenas-Navia, Isabel, Teer, Jamie K, Lin, Jimmy C, Walia, Vijay, Gartner, Jared, Jiang, Jiji, Cherukuri, Praveen F, Molinolo, Alfredo, Davies, Michael A, Gershenwald, Jeffrey E, Stemke-Hale, Katherine, Rosenberg, Steven A, Margulies, Elliott H, Samuels, Yardena
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376644/
https://ncbi.nlm.nih.gov/pubmed/21946352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.950
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