Somatic mutations in MAP3K5 attenuate its pro-apoptotic function in melanoma through increased binding to Thioredoxin

Patients with advanced metastatic melanoma have poor prognosis and the genetics underlying its pathogenesis are poorly understood. High throughput sequencing has allowed comprehensive discovery of somatic mutations in cancer samples. Here, upon analysis of our whole-genome and whole-exome sequencing...

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Detaylı Bibliyografya
Asıl Yazarlar: Prickett, Todd D., Zerlanko, Brad, Gartner, Jared J., Parker, Stephen C. J., Dutton-Regester, Ken, Lin, Jimmy C., Teer, Jamie K., Wei, Xiaomu, Jiang, Jiji, Chen, Guo, Davies, Michael A., Gershenwald, Jeffrey E., Robinson, William, Robinson, Steven, Hayward, Nicholas K., Rosenberg, Steven, A., Margulies, Elliott H., Samuels, Yardena
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947167/
https://ncbi.nlm.nih.gov/pubmed/24008424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.365
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