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Novel somatic mutations in heterotrimeric G proteins in melanoma

Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate signals between G-protein coupled receptors and their downstream pathways, and have been shown to be mutated in cancer. In particular, GNAQ was found to be frequently mutated in blue nevi of the skin and uveal melanoma, acting a...

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Hlavní autoři: Cárdenas-Navia, L Isabel, Cruz, Pedro, Lin, Jimmy C, Rosenberg, Steven A, Samuels, Yardena
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040832/
https://ncbi.nlm.nih.gov/pubmed/20424519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.1.11949
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