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Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1
OBJECTIVES: Aspirin, a major anti-platelet and cancer preventing drug, irreversibly blocks the cyclooxygenase activity of prostaglandin H synthase-1 (PGHS-1). Considerable differences in aspirin effectiveness are observed between individuals, and some of this variability may be due to PGHS-1 protein...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376194/ https://ncbi.nlm.nih.gov/pubmed/22513397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835366f6 |
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