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CYCLOOXYGENASE COMPETITIVE INHIBITORS ALTER TYROSYL RADICAL DYNAMICS IN PROSTAGLANDIN H SYNTHASE-2

Reaction of prostaglandin H synthase (PGHS) isoforms 1 or 2 with peroxide forms a radical at Tyr385 that is required for cyclooxygenase catalysis, and another radical at Tyr504, whose function is unknown. Both tyrosyl radicals are transient and rapidly dissipated by reductants, suggesting that cyclo...

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書誌詳細
主要な著者: Wu, Gang, Tsai, Ah-Lim, Kulmacz, Richard J.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805951/
https://ncbi.nlm.nih.gov/pubmed/19894761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901600f
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