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CYCLOOXYGENASE REACTION MECHANISM OF PROSTAGLANDIN H SYNTHASE FROM DEUTERIUM KINETIC ISOTOPE EFFECTS
Cyclooxygenase catalysis by prostaglandin H synthase (PGHS) is thought to involve a multistep mechanism with several radical intermediates. The proposed mechanism begins with transfer of the C13 pro-(S) hydrogen atom from the substrate arachidonic acid (AA) to the Tyr385 radical in PGHS, followed by...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049311/ https://ncbi.nlm.nih.gov/pubmed/21394223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2010.11.015 |
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