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Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors
The cyclooxygenase (COX) activity of prostaglandin H synthase-2 (PGHS-2) is implicated in colorectal cancer and is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) and dietary n – 3 fatty acids. We used purified, recombinant proteins to evaluate the functional impacts of the R228H, E488G, V...
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| Udgivet i: | Pharmacogenomics J |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465550/ https://ncbi.nlm.nih.gov/pubmed/20548327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2010.49 |
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