Загрузка...
Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors
Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test “loop grafting,” a rational design method, on three-finger fold proteins. These small reticulated proteins have exceptional affinity and specificity for their di...
Сохранить в:
| Главные авторы: | , , , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2012
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375269/ https://ncbi.nlm.nih.gov/pubmed/22720062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039166 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|