Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test “loop grafting,” a rational design method, on three-finger fold proteins. These small reticulated proteins have exceptional affinity and specificity for their di...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Fruchart-Gaillard, Carole, Mourier, Gilles, Blanchet, Guillaume, Vera, Laura, Gilles, Nicolas, Ménez, Renée, Marcon, Elodie, Stura, Enrico A., Servent, Denis
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375269/
https://ncbi.nlm.nih.gov/pubmed/22720062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039166
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы