Copper mediated amyloid-β binding to Transthyretin

Transthyretin (TTR), a homotetrameric protein that transports thyroxine and retinol both in plasma and in cerebrospinal (CSF) fluid provides a natural protective response against Alzheimer’s disease (AD), modulates amyloid-β (Aβ) deposition by direct interaction and co-localizes with Aβ in plaques....

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Udgivet i:Sci Rep
Main Authors: Ciccone, Lidia, Fruchart-Gaillard, Carole, Mourier, Gilles, Savko, Martin, Nencetti, Susanna, Orlandini, Elisabetta, Servent, Denis, Stura, Enrico A., Shepard, William
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137083/
https://ncbi.nlm.nih.gov/pubmed/30213975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31808-5
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