Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test “loop grafting,” a rational design method, on three-finger fold proteins. These small reticulated proteins have exceptional affinity and specificity for their di...

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Main Authors: Fruchart-Gaillard, Carole, Mourier, Gilles, Blanchet, Guillaume, Vera, Laura, Gilles, Nicolas, Ménez, Renée, Marcon, Elodie, Stura, Enrico A., Servent, Denis
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375269/
https://ncbi.nlm.nih.gov/pubmed/22720062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039166
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