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Structural Model of Ligand-G Protein-coupled Receptor (GPCR) Complex Based on Experimental Double Mutant Cycle Data: MT7 SNAKE TOXIN BOUND TO DIMERIC hM1 MUSCARINIC RECEPTOR

The snake toxin MT7 is a potent and specific allosteric modulator of the human M1 muscarinic receptor (hM1). We previously characterized by mutagenesis experiments the functional determinants of the MT7-hM1 receptor interaction (Fruchart-Gaillard, C., Mourier, G., Marquer, C., Stura, E., Birdsall, N...

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Detalhes bibliográficos
Main Authors: Marquer, Catherine, Fruchart-Gaillard, Carole, Letellier, Guillaume, Marcon, Elodie, Mourier, Gilles, Zinn-Justin, Sophie, Ménez, André, Servent, Denis, Gilquin, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173127/
https://ncbi.nlm.nih.gov/pubmed/21685390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261404
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