Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM(1), hM(2), hM(3), hM(4) and hM(5) using microphysiometry

1. This study describes the pharmacological comparison of the muscarinic partial agonists sabcomeline, xanomeline and milameline at human cloned muscarinic receptor subtypes (hM(1–5)). 2. Radioligand binding studies at the hM(1–5) muscarinic receptor subtypes were compared with functional studies us...

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Autori principali: Wood, Martyn D, Murkitt, Karen L, Ho, Michael, Watson, Jeannette M, Brown, Frank, Hunter, A Jacqueline, Middlemiss, Derek N
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565933/
https://ncbi.nlm.nih.gov/pubmed/10323594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702463
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