Orthosteric Binding of ρ-Da1a, a Natural Peptide of Snake Venom Interacting Selectively with the α(1A)-Adrenoceptor

ρ-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the α(1A)-adrenoceptor. This toxin has atypical pharmacological properties, including incomplete inhibition of (3)H-prazosin or (125)I-HEAT binding and insurmountable antagonist action. We aimed to clarify its mo...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Maïga, Arhamatoulaye, Merlin, Jon, Marcon, Elodie, Rouget, Céline, Larregola, Maud, Gilquin, Bernard, Fruchart-Gaillard, Carole, Lajeunesse, Evelyne, Marchetti, Charles, Lorphelin, Alain, Bellanger, Laurent, Summers, Roger J., Hutchinson, Dana S., Evans, Bronwyn A., Servent, Denis, Gilles, Nicolas
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2013
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723878/
https://ncbi.nlm.nih.gov/pubmed/23935897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068841
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