Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α(2)-adrenoceptors

BACKGROUND AND PURPOSE: Muscarinic and adrenergic G protein-coupled receptors (GPCRs) are the targets of rare peptide toxins isolated from snake or cone snail venoms. We used a screen to identify novel toxins from Dendroaspis angusticeps targeting aminergic GPCRs. These toxins may offer new candidat...

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Bibliographic Details
Main Authors: Rouget, Céline, Quinton, Loïc, Maïga, Arhamatoulaye, Gales, Céline, Masuyer, Geoffrey, Malosse, Christian, Chamot-Rooke, Julia, Thai, Robert, Mourier, Gilles, de Pauw, Edwin, Gilles, Nicolas, Servent, Denis
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000660/
https://ncbi.nlm.nih.gov/pubmed/20659106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00966.x
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