DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions

Low-fidelity DNA polymerases introduce nucleotide substitutions in immunoglobulin variable regions during somatic hypermutation. Although DNA polymerase (pol) η is the major low-fidelity polymerase, other DNA polymerases may also contribute. Existing data are contradictory as to whether pol ζ is inv...

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Hlavní autoři: Saribasak, Huseyin, Maul, Robert W., Cao, Zheng, Yang, William W., Schenten, Dominik, Kracker, Sven, Gearhart, Patricia J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371727/
https://ncbi.nlm.nih.gov/pubmed/22615128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112234
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