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Hijacked DNA repair proteins and unchained DNA polymerases
Somatic hypermutation of immunoglobulin (Ig) genes occurs at a frequency that is a million times greater than the mutation in other genes. Mutations occur in variable genes to increase antibody affinity, and in switch regions before constant genes to cause switching from IgM to IgG. Hypermutation is...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660914/ https://ncbi.nlm.nih.gov/pubmed/19008198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2008.0188 |
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